Axolotl salamanders are unique in their ability to regenerate lost limbs throughout their adult lives (Figure 1).  During limb regeneration, all parts of the mature limb must reform, including the cartilage skeleton.  Bone morphogenetic proteins (BMPs) are signal molecules vital to the formation of cartilage (chondrogenesis) in vertebrate embryos.  If limb regeneration follows many of the same molecular pathways as limb development, it is predicted that BMP will be present in the regenerating limb.  Studies have shown BMP is present in regenerating limbs.  Based on this evidence, we hypothesized that the receptor protein involved in chondrogenesis, type I BMP receptor B (BmprIb), will also be expressed in the regenerating axolotl limb.  Regenerating tissue from Ambystoma mexicanum, the Mexican axolotl, was screened for the presence of the active BmprIb gene using RT-PCR.  Our results do not conclusively confirm the presence or absence of BmprIb mRNA in the samples.  Additional testing will be required.